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Taurursodiol

CHEMBL272427 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
499.7 g/mol
LogP
3.6
Phase
4

Taurursodiol (sodium phenylbutyrate/ursodoxicoltaurine, also known as AMX0035) is a fixed-dose combination product that modulates endoplasmic reticulum stress and mitochondrial dysfunction, reducing neuronal and motor neuron apoptosis. It is approved for the treatment of amyotrophic lateral sclerosis (ALS) and is under investigation for neurodegenerative diseases. By targeting two complementary pathways of cell death, it offers a novel approach to neuroprotection.

分子量

499.7000 g/mol

LogP

3.60

TPSA

132.00 Ų

リピンスキーの五則

適合

治療領域

Asthma Multiple Sclerosis Obesity Type 2 Diabetes Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

                

                

                
                

                    
InChI

                    
InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H45NO6S

                    

                    
                    

                        
HBD / HBA

                        
4 / 6

                    

                    
                    

                        
回転可能結合数

                        
7

                    

                    
                    
                    

                        
重原子数

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Taurursodiol (sodium phenylbutyrate/ursodoxicoltaurine, also known as AMX0035) is a fixed-dose combination product that modulates endoplasmic reticulum stress and mitochondrial dysfunction, reducing neuronal and motor neuron apoptosis. It is approved for the treatment of amyotrophic lateral sclerosis (ALS) and is under investigation for neurodegenerative diseases. By targeting two complementary pathways of cell death, it offers a novel approach to neuroprotection.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Taurursodiol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL272427.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9848818.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.