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Temoporfin

CHEMBL500576 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
680.7 g/mol
LogP
8.8
Phase
4

Temoporfin (mTHPC, Foscan) is a second-generation photosensitizer used in photodynamic therapy (PDT) for head and neck squamous cell carcinoma and non-small cell lung cancer, where it accumulates preferentially in tumor tissue and, upon activation by 652 nm laser light, generates cytotoxic singlet oxygen and free radicals that destroy tumor cells. It is significantly more potent than first-generation porphyrin photosensitizers, requiring lower doses of drug and light. Its primary limitation is prolonged photosensitivity requiring extended sun avoidance after administration.

分子量

680.7000 g/mol

LogP

8.80

TPSA

138.00 Ų

リピンスキーの五則

不適合

治療領域

Non-Small Cell Lung Cancer

作用機序

Accumulates in target tissues and generates reactive oxygen species upon activation by specific wavelengths of light, causing localized cellular damage and destruction of pathological tissue.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Accumulates in target tissues and generates reactive oxygen species upon activation by specific wavelengths of light, causing localized cellular damage and destruction of pathological tissue.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Oc1cccc(-c2c3nc(c(-c4cccc(O)c4)c4ccc([nH]4)c(-c4cccc(O)c4)c4nc(c(-c5cccc(O)c5)c5ccc2[nH]5)CC4)C=C3)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-

                

                

                

                    
                    

                        
Molecular Formula

                        
C44H32N4O4

                    

                    
                    

                        
HBD / HBA

                        
6 / 6

                    

                    
                    

                        
回転可能結合数

                        
4

                    

                    
                    
                    

                        
重原子数

                        
52

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Temoporfin (mTHPC, Foscan) is a second-generation photosensitizer used in photodynamic therapy (PDT) for head and neck squamous cell carcinoma and non-small cell lung cancer, where it accumulates preferentially in tumor tissue and, upon activation by 652 nm laser light, generates cytotoxic singlet oxygen and free radicals that destroy tumor cells. It is significantly more potent than first-generation porphyrin photosensitizers, requiring lower doses of drug and light. Its primary limitation is prolonged photosensitivity requiring extended sun avoidance after administration.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Accumulates in target tissues and generates reactive oxygen species upon activation by specific wavelengths of light, causing localized cellular damage and destruction of pathological tissue.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Temoporfin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL500576.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60751.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.