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Tigecycline

CHEMBL376140 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
585.6 g/mol
LogP
1.1
Phase
4

This broad-spectrum antibiotic is given intravenously in hospital settings to treat serious infections including complicated skin infections, abdominal infections, and community-acquired pneumonia caused by bacteria resistant to other antibiotics. It belongs to the glycylcycline class and works by blocking bacterial protein synthesis. It carries a boxed warning for increased risk of death in some settings compared to other antibiotics.

分子量

585.6000 g/mol

LogP

1.10

TPSA

206.00 Ų

リピンスキーの五則

不適合

治療領域

Infectious Disease Obesity Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O

                

                

                
                

                    
InChI

                    
InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C29H39N5O8

                    

                    
                    

                        
HBD / HBA

                        
7 / 11

                    

                    
                    

                        
回転可能結合数

                        
7

                    

                    
                    
                    

                        
重原子数

                        
42

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
This broad-spectrum antibiotic is given intravenously in hospital settings to treat serious infections including complicated skin infections, abdominal infections, and community-acquired pneumonia caused by bacteria resistant to other antibiotics. It belongs to the glycylcycline class and works by blocking bacterial protein synthesis. It carries a boxed warning for increased risk of death in some settings compared to other antibiotics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tigecycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL376140.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 54686904.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.