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Tiludronic Acid

CHEMBL1350 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
318.6 g/mol
LogP
-0.3
Phase
4

Tiludronic acid is a second-generation bisphosphonate that inhibits osteoclast-mediated bone resorption by inhibiting farnesyl pyrophosphate synthase in the mevalonate pathway, reducing geranylgeranylation of small GTPase signaling proteins essential for osteoclast function. It is approved for the treatment of Paget's disease of bone (osteitis deformans) to reduce elevated bone turnover, decrease bone pain, and normalize alkaline phosphatase levels. Its bisphosphonate mechanism provides durable suppression of osteoclast activity through direct binding to hydroxyapatite.

分子量

318.6100 g/mol

LogP

-0.30

TPSA

140.00 Ų

リピンスキーの五則

適合

治療領域

Osteoporosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=P(O)(O)C(Sc1ccc(Cl)cc1)P(=O)(O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14)

                

                

                

                    
                    

                        
Molecular Formula

                        
C7H9ClO6P2S

                    

                    
                    

                        
HBD / HBA

                        
4 / 7

                    

                    
                    

                        
回転可能結合数

                        
4

                    

                    
                    
                    

                        
重原子数

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Tiludronic acid is a second-generation bisphosphonate that inhibits osteoclast-mediated bone resorption by inhibiting farnesyl pyrophosphate synthase in the mevalonate pathway, reducing geranylgeranylation of small GTPase signaling proteins essential for osteoclast function. It is approved for the treatment of Paget's disease of bone (osteitis deformans) to reduce elevated bone turnover, decrease bone pain, and normalize alkaline phosphatase levels. Its bisphosphonate mechanism provides durable suppression of osteoclast activity through direct binding to hydroxyapatite.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tiludronic Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1350.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60937.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.