Tipiracil
Tipiracil is a thymidine phosphorylase inhibitor that blocks the enzymatic degradation of trifluridine (TAS-102 combination partner) in the gut and blood, maintaining therapeutic trifluridine plasma concentrations. When combined with trifluridine, it enables sufficient systemic trifluridine exposure to incorporate into tumor cell DNA and inhibit thymidylate synthase, exerting cytotoxic effects. The combination is approved for refractory metastatic colorectal cancer and gastric cancer.
分子量
242.6600 g/mol
LogP
-0.70
TPSA
85.30 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
N=C1CCCN1Cc1[nH]c(=O)[nH]c(=O)c1Cl
InChI
InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)
Molecular Formula
C9H11ClN4O2
HBD / HBA
3 / 3
回転可能結合数
2
重原子数
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Tipiracil is a thymidine phosphorylase inhibitor that blocks the enzymatic degradation of trifluridine (TAS-102 combination partner) in the gut and blood, maintaining therapeutic trifluridine plasma concentrations. When combined with trifluridine, it enables sufficient systemic trifluridine exposure to incorporate into tumor cell DNA and inhibit thymidylate synthase, exerting cytotoxic effects. The combination is approved for refractory metastatic colorectal cancer and gastric cancer.
Yes, Tipiracil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL235668. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6323266. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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