Triclosan
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, antimicrobial resistance selection, and lack of proven clinical benefit.
分子量
289.5000 g/mol
LogP
5.00
TPSA
29.50 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
InChI
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
Molecular Formula
C12H7Cl3O2
HBD / HBA
1 / 2
回転可能結合数
2
重原子数
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, …
Yes, Triclosan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL849. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5564. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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