Trimethaphan

CHEMBL1201329 Phase 4 承認済み Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

365.5 g/mol

LogP

3.6

Phase

4

Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

分子量

365.5000 g/mol

LogP

3.60

TPSA

24.60 Å²

リピンスキーの五則

適合

治療領域

Obesity Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

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SMILES

O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

InChI

InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

Molecular Formula

C22H25N2OS+

HBD / HBA

- / 1

回転可能結合数

4

重原子数

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

よくある質問

Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

Yes, Trimethaphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201329. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 23576. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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構造

クイックデータ

分子式: C22H25N2OS+

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医学的免責事項

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.