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Trimethoprim Hydrochloride

CHEMBL1201080 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
326.8 g/mol
LogP
—
Phase
4

A hydrochloride salt form of trimethoprim with the same therapeutic properties. This antibiotic is used to treat and prevent urinary tract infections and is often combined with sulfamethoxazole (as co-trimoxazole or Bactrim) to treat a broader range of infections including certain types of pneumonia.

分子量

326.7800 g/mol

TPSA

106.00 Ų

治療領域

Infectious Disease Bladder Cancer Benign Prostatic Hyperplasia Glaucoma Age-Related Macular Degeneration Hematology Chronic Obstructive Pulmonary Disease Schizophrenia Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Obesity Lymphoma Breast Cancer Atopic Dermatitis Malaria HIV/AIDS Tuberculosis Prostate Cancer Leukemia

作用機序

Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Dihydrofolate reductase inhibitor (bacterial selective).

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C14H18N4O3.ClH/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;/h5-7H,4H2,1-3H3,(H4,15,16,17,18);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H19ClN4O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 7

                    

                    
                    

                        
回転可能結合数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A hydrochloride salt form of trimethoprim with the same therapeutic properties. This antibiotic is used to treat and prevent urinary tract infections and is often combined with sulfamethoxazole (as co-trimoxazole or Bactrim) to treat a broader range of infections including certain types of pneumonia.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Dihydrofolate reductase inhibitor (bacterial selective).

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Trimethoprim Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201080.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 173769.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.