Vinflunine Ditartrate
Vinflunine ditartrate is the ditartrate salt form of vinflunine, a third-generation fluorinated vinca alkaloid antineoplastic agent used for advanced urothelial carcinoma. The ditartrate salt provides aqueous solubility for intravenous administration. Its mechanism involves tubulin binding at the vinca domain with suppression of microtubule dynamic instability and inhibition of mitotic progression.
分子量
1117.1000 g/mol
TPSA
364.00 Ų
作用機序
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
2D構造
Cite this structure
Embed this structure
SMILES
CC[C@]12C=CCN3CC[C@@]4(c5cc([C@@]6(C(=O)OC)C[C@@H]7C[C@@H](C(C)(F)F)CN(Cc8c6[nH]c6ccccc86)C7)c(OC)cc5N(C)[C@H]4[C@@](O)(C(=O)OC)[C@@H]1OC(C)=O)[C@@H]32.O=C(O)C(O)C(O)C(=O)O.O=C(O)C(O)C(O)C(=O)O
InChI
InChI=1S/C45H54F2N4O8.2C4H6O6/c1-8-42-14-11-16-51-17-15-43(36(42)51)30-19-31(34(56-5)20-33(30)49(4)37(43)45(55,40(54)58-7)38(42)59-25(2)52)44(39(53)57-6)21-26-18-27(41(3,46)47)23-50(22-26)24-29-28-12-9-10-13-32(28)48-35(29)44;2*5-1(3(7)8)2(6)4(9)10/h9-14,19-20,26-27,36-38,48,55H,8,15-18,21-24H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t26-,27+,36-,37+,38+,42+,43+,44-,45-;;/m0../s1
Molecular Formula
C53H66F2N4O20
HBD / HBA
10 / 25
回転可能結合数
16
重原子数
79
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Vinflunine ditartrate is the ditartrate salt form of vinflunine, a third-generation fluorinated vinca alkaloid antineoplastic agent used for advanced urothelial carcinoma. The ditartrate salt provides aqueous solubility for intravenous administration. Its mechanism involves tubulin binding at the vinca domain with suppression of microtubule dynamic instability and inhibition of mitotic progression.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Vinflunine Ditartrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105629. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 16220212. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="vinflunine-ditartrate"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/vinflunine-ditartrate/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/vinflunine-ditartrate/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/vinflunine-ditartrate/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="vinflunine-ditartrate"></drugfyi-drug>