Zavegepant Hydrochloride
Zavegepant hydrochloride is the hydrochloride salt form of zavegepant, an intranasal CGRP receptor antagonist for acute migraine treatment. The hydrochloride salt form provides appropriate physicochemical properties for the aqueous intranasal spray formulation. Like the free base, it blocks CGRP receptors in trigeminal afferents and meningeal blood vessels to abort acute migraine attacks.
分子量
675.3000 g/mol
TPSA
117.00 Ų
作用機序
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D構造
Cite this structure
Embed this structure
SMILES
Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn[nH]c12.Cl
InChI
InChI=1S/C36H46N8O3.ClH/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45;/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47);1H/t32-;/m1./s1
Molecular Formula
C36H47ClN8O3
HBD / HBA
4 / 6
回転可能結合数
6
重原子数
48
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Zavegepant hydrochloride is the hydrochloride salt form of zavegepant, an intranasal CGRP receptor antagonist for acute migraine treatment. The hydrochloride salt form provides appropriate physicochemical properties for the aqueous intranasal spray formulation. Like the free base, it blocks CGRP receptors in trigeminal afferents and meningeal blood vessels to abort acute migraine attacks.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Zavegepant Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4650220. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 134819878. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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