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Zidovudine

CHEMBL129 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
267.2 g/mol
LogP
—
Phase
4

First approval for any HIV treatment went to zidovudine, still widely known as AZT, and the drug inhibits reverse transcriptase, the enzyme the virus requires to copy its RNA genome into DNA. Blocking that conversion halts replication within infected cells. Contemporary use places it inside combination antiretroviral regimens rather than alone, and it retains a specific role in preventing mother-to-child transmission, given to pregnant women with HIV and to their newborn infants. Bone marrow suppression with resulting anaemia is the principal toxicity and the reason haematological monitoring accompanies treatment. The molecule is small, C10H13N5O4 at about 267.2 g/mol, and it is approved with development completed through the final phase.

This antiretroviral medication (also known as AZT) was the first approved treatment for HIV infection and works by blocking reverse transcriptase, an enzyme the virus needs to copy its genetic material. It is now used as part of combination antiretroviral therapy and is also given to HIV-positive pregnant women and their newborns to reduce the risk of transmitting HIV from mother to child. Bone marrow suppression causing anemia is the main side effect requiring monitoring.

分子量

267.2400 g/mol

LogP

0.00

TPSA

93.20 Ų

リピンスキーの五則

適合

治療領域

Hematology HIV/AIDS

作用機序

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H13N5O4

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
回転可能結合数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
This antiretroviral medication (also known as AZT) was the first approved treatment for HIV infection and works by blocking reverse transcriptase, an enzyme the virus needs to copy its genetic material. It is now used as part of combination antiretroviral therapy and is also given to HIV-positive pregnant women and their newborns to reduce the risk of transmitting HIV from mother to child. Bone marrow suppression causing anemia is the main side effect requiring monitoring.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zidovudine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL129.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 35370.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.