Minor
Suspected
説明
Doxycycline may slightly raise atorvastatin plasma levels through weak inhibition of CYP3A4 and P-glycoprotein, though clinically significant myopathy from this combination is rarely reported.
機序
Doxycycline has weak inhibitory activity on CYP3A4 and P-gp, which are involved in atorvastatin metabolism and efflux; modest increases in atorvastatin exposure could marginally raise myopathy risk.
臨床的意義
There are isolated case reports of statin myopathy with tetracyclines; formal pharmacokinetic studies demonstrating a clinically relevant interaction are lacking.
対処法
No dose adjustment required; counsel patients on muscle symptoms during antibiotic course; investigate CK elevation if myopathy is suspected.