Minor
Suspected
説明
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.
機序
Acid suppression by ranitidine can alter the dissolution rate of cephalexin capsules, potentially delaying Tmax; total absorption (AUC) is largely unaffected.
臨床的意義
No clinically meaningful reduction in cephalexin efficacy has been documented; the interaction is considered theoretical.
対処法
No dose adjustment or timing modification is required.