Major
Probable
説明
Ciprofloxacin and ondansetron both prolong the QT interval; combined use raises the risk of torsades de pointes and sudden cardiac death.
機序
Both agents block hERG (IKr) cardiac potassium channels; additive QTc prolongation results from concurrent administration.
臨床的意義
Fluoroquinolones are a well-established class of QT-prolonging drugs; post-marketing data link the combination to arrhythmia events.
対処法
Avoid when possible; if both are medically necessary, obtain baseline and follow-up ECG and correct electrolyte abnormalities.