Major
Established
説明
Concurrent use of diazepam and oxycodone dramatically increases the risk of fatal respiratory depression, per FDA boxed warning.
機序
Additive CNS depression via GABA-A (diazepam) and mu-opioid receptor (oxycodone) pathways; concurrent use reduces hypoxic ventilatory response.
臨床的意義
Patients receiving both agents show substantially higher rates of emergency department visits and overdose deaths.
対処法
Avoid combination or use the lowest possible doses for the shortest duration; co-prescribe naloxone and educate patients.