Major
Probable
説明
Diazepam and quetiapine together significantly increase CNS depression and carry risk of severe sedation and cardiorespiratory compromise.
機序
Additive CNS depression through complementary receptor mechanisms (GABA-A vs. H1/alpha-1/D2 blockade); quetiapine also prolongs QT, adding cardiac risk.
臨床的意義
Excess sedation and cardiovascular events are documented with the combination; particularly risky in elderly or medically ill patients.
対処法
Use at minimum doses only when clearly indicated; monitor sedation level, ECG, and vital signs.