Major
Established
説明
Diazepam and zolpidem together produce compounded GABA-A-mediated CNS depression, with risk of severe sedation and respiratory compromise.
機序
Additive enhancement of GABA-A inhibitory neurotransmission; diazepam has longer duration of action which prolongs the interaction window.
臨床的意義
Excess sedation, anterograde amnesia, and impaired psychomotor function are reliably increased with dual GABA-A modulator use.
対処法
Avoid combination; if a hypnotic is needed during benzodiazepine therapy, optimize the benzodiazepine regimen first.