Moderate
Probable
説明
Fluconazole inhibits CYP2C19 and CYP3A4, increasing sertraline plasma concentrations, which may enhance both therapeutic and adverse effects including QT prolongation.
機序
Fluconazole reduces sertraline clearance via CYP2C19 and CYP3A4 inhibition; higher sertraline levels increase serotonergic tone and may modestly prolong QTc.
臨床的意義
Sertraline AUC is significantly increased with fluconazole co-administration; clinical monitoring for adverse effects is warranted.
対処法
Monitor for sertraline side effects; consider sertraline dose reduction during fluconazole courses; obtain ECG if prolonged co-administration.