Moderate
Probable
説明
Sertraline may increase lamotrigine plasma concentrations by inhibiting its glucuronidation, potentially causing lamotrigine toxicity.
機序
Sertraline inhibits UGT enzymes responsible for lamotrigine glucuronidation, particularly UGT1A4, resulting in reduced lamotrigine clearance.
臨床的意義
Lamotrigine levels may increase significantly; symptoms of lamotrigine toxicity (diplopia, dizziness, ataxia) may develop.
対処法
Monitor lamotrigine levels and for toxicity symptoms when sertraline is added; lamotrigine dose reduction may be required.