Afatinib vs Gefitinib

## Afatinib vs Gefitinib: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Gefitinib**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Gefitinib**: Selective reversible inhibitor of EGFR tyrosine kinase.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Gefitinib — 48 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Gefitinib — C22H24ClFN4O3.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Gefitinib — 446.9000 g/mol.

**Type**: Afatinib — Small molecule; Gefitinib — Small molecule.