Allopurinol vs Tofacitinib

## Allopurinol vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Allopurinol** and **Tofacitinib**.

## Mechanism of Action

**Allopurinol**: Xanthine oxidase inhibitor reducing uric acid production.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Allopurinol — 1-2 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Allopurinol — C5H4N4O; Tofacitinib — C16H20N6O.

**Molecular Weight**: Allopurinol — 136.1120 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Allopurinol — Small molecule; Tofacitinib — Small molecule.