Diphenhydramine vs Zolpidem

## Diphenhydramine vs Zolpidem: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Zolpidem**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Zolpidem**: Selective GABA-A receptor alpha-1 subunit agonist.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Zolpidem — 2.5 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Zolpidem — C19H21N3O.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Zolpidem — 307.3950 g/mol.

**Type**: Diphenhydramine — Small molecule; Zolpidem — Small molecule.