Fluconazole vs Trimethoprim

## Fluconazole vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Fluconazole** and **Trimethoprim**.

## Mechanism of Action

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Fluconazole — 30 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Fluconazole — C13H12F2N6O; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Fluconazole — 306.2710 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Fluconazole — Small molecule; Trimethoprim — Small molecule.