Hydrochlorothiazide vs Lorazepam

## Hydrochlorothiazide vs Lorazepam: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Lorazepam**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Lorazepam**: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Lorazepam — 10-20 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Lorazepam — C15H10Cl2N2O2.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Lorazepam — 321.1580 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Lorazepam — Small molecule.