Hydrochlorothiazide vs Methylprednisolone

## Hydrochlorothiazide vs Methylprednisolone: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Methylprednisolone**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Methylprednisolone**: Intermediate-acting synthetic glucocorticoid.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Methylprednisolone — 18-36 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Methylprednisolone — C22H30O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Methylprednisolone — 374.4710 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Methylprednisolone — Small molecule.