Irbesartan vs Sildenafil

## Irbesartan vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Irbesartan** and **Sildenafil**.

## Mechanism of Action

**Irbesartan**: Selective non-competitive angiotensin II type 1 receptor antagonist.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Irbesartan — 11-15 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Irbesartan — C25H28N6O; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Irbesartan — 428.5320 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Irbesartan — Small molecule; Sildenafil — Small molecule.