Naproxen vs Tofacitinib

## Naproxen vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Naproxen** and **Tofacitinib**.

## Mechanism of Action

**Naproxen**: Non-selective COX inhibitor.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Naproxen — 12-17 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Naproxen — C14H14O3; Tofacitinib — C16H20N6O.

**Molecular Weight**: Naproxen — 230.2590 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Naproxen — Small molecule; Tofacitinib — Small molecule.