Paroxetine vs Tofacitinib

## Paroxetine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Paroxetine** and **Tofacitinib**.

## Mechanism of Action

**Paroxetine**: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Paroxetine — 21 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Paroxetine — C19H20FNO3; Tofacitinib — C16H20N6O.

**Molecular Weight**: Paroxetine — 329.3730 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Paroxetine — Small molecule; Tofacitinib — Small molecule.