Sildenafil vs Upadacitinib

## Sildenafil vs Upadacitinib: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Upadacitinib**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Upadacitinib**: Selective JAK1 inhibitor reducing signaling from cytokines implicated in autoimmune diseases.

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Upadacitinib — 9-14 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Upadacitinib — C17H19F3N6O.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Upadacitinib — 380.3700 g/mol.

**Type**: Sildenafil — Small molecule; Upadacitinib — Small molecule.