Sitagliptin vs Upadacitinib

## Sitagliptin vs Upadacitinib: Overview

This comparison examines the pharmacological differences between **Sitagliptin** and **Upadacitinib**.

## Mechanism of Action

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

**Upadacitinib**: Selective JAK1 inhibitor reducing signaling from cytokines implicated in autoimmune diseases.

## Pharmacokinetics

**Half-life**: Sitagliptin — 12.4 hours; Upadacitinib — 9-14 hours.

## Chemical Properties

**Molecular Formula**: Sitagliptin — C16H15F6N5O; Upadacitinib — C17H19F3N6O.

**Molecular Weight**: Sitagliptin — 407.3140 g/mol; Upadacitinib — 380.3700 g/mol.

**Type**: Sitagliptin — Small molecule; Upadacitinib — Small molecule.