Spironolactone vs Tacrolimus

## Spironolactone vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Spironolactone** and **Tacrolimus**.

## Mechanism of Action

**Spironolactone**: Mineralocorticoid receptor antagonist.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Spironolactone — 1.4 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Spironolactone — C24H32O4S; Tacrolimus — C44H69NO12.

**Molecular Weight**: Spironolactone — 416.5740 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Spironolactone — Small molecule; Tacrolimus — Small molecule.