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Dasabuvir

CHEMBL3137312 Phase 4 승인됨 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
493.6 g/mol
LogP
4.3
Phase
4

A non-nucleoside NS5B polymerase inhibitor that blocks hepatitis C virus RNA replication, used as part of a combination direct-acting antiviral regimen for chronic hepatitis C genotype 1. It is typically co-administered with ombitasvir and paritaprevir/ritonavir.

분자량

493.6000 g/mol

LogP

4.30

TPSA

113.00 Ų

리핀스키 5의 법칙

통과

치료 영역

Hepatitis C

작용 기전

Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

기전

Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1c(-c2ccc3cc(NS(C)(=O)=O)ccc3c2)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H27N3O5S

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
회전 가능 결합

                        
6

                    

                    
                    
                    

                        
무거운 원자

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
A non-nucleoside NS5B polymerase inhibitor that blocks hepatitis C virus RNA replication, used as part of a combination direct-acting antiviral regimen for chronic hepatitis C genotype 1. It is typically co-administered with ombitasvir and paritaprevir/ritonavir.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Dasabuvir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3137312.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 56640146.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.