Olezarsen Sodium
A sodium salt form of olezarsen, an antisense oligonucleotide that reduces liver production of apolipoprotein C-III, thereby lowering triglyceride levels in patients with severe hypertriglyceridemia or familial chylomicronemia syndrome. It helps prevent pancreatitis related to extremely high triglyceride levels.
작용 기전
Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
A sodium salt form of olezarsen, an antisense oligonucleotide that reduces liver production of apolipoprotein C-III, thereby lowering triglyceride levels in patients with severe hypertriglyceridemia or familial chylomicronemia syndrome. It helps prevent pancreatitis related to extremely high triglyceride levels.
Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.
Yes, Olezarsen Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Oligonucleotide.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4650263. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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