Sertindole
Sertindole is an atypical antipsychotic of the phenylindole class with high affinity for dopamine D2, serotonin 5-HT2A, and alpha-1 adrenergic receptors, used for the treatment of schizophrenia and investigated in bipolar disorder and generalized anxiety disorder. Its unique receptor binding profile, with greater affinity for mesolimbic versus nigrostriatal dopamine pathways, provides antipsychotic efficacy with reduced extrapyramidal side effects. QTc prolongation risk limits its use and requires cardiac monitoring.
분자량
440.9000 g/mol
LogP
4.10
TPSA
40.50 Ų
리핀스키 5의 법칙
통과
치료 영역
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D 구조
Cite this structure
Embed this structure
SMILES
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1
InChI
InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
Molecular Formula
C24H26ClFN4O
HBD / HBA
1 / 3
회전 가능 결합
5
무거운 원자
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
Sertindole is an atypical antipsychotic of the phenylindole class with high affinity for dopamine D2, serotonin 5-HT2A, and alpha-1 adrenergic receptors, used for the treatment of schizophrenia and investigated in bipolar disorder and generalized anxiety disorder. Its unique receptor binding profile, with greater affinity for mesolimbic versus nigrostriatal dopamine pathways, provides antipsychotic efficacy with reduced extrapyramidal side effects. QTc prolongation risk limits its use and requires cardiac monitoring.
Yes, Sertindole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL12713. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60149. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="sertindole"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/sertindole/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/sertindole/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/sertindole/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="sertindole"></drugfyi-drug>