Major
Probable
설명
Co-administration of alprazolam and quetiapine produces additive CNS depression with risk of profound sedation and respiratory compromise.
기전
Both agents have CNS depressant properties via distinct receptors: alprazolam via GABA-A and quetiapine via H1/D2/alpha-1 receptor blockade; additive inhibitory effects on CNS excitability occur.
임상적 중요성
The combination is associated with excess mortality in pharmacoepidemiological data, particularly in elderly patients with psychiatric illness.
관리 방법
Use with caution; monitor closely for excessive sedation and respiratory depression; avoid in patients with sleep apnea.