설명

Combining aspirin with celecoxib provides no additional gastroprotective benefit over aspirin alone and may negate the GI advantage of celecoxib, increasing the risk of mucosal injury.

기전

Aspirin inhibits COX-1 (and to a lesser extent COX-2), causing gastric mucosal injury; celecoxib's GI safety advantage over non-selective NSAIDs is largely lost when aspirin is co-administered.

임상적 중요성

The CLASS trial showed that the GI safety advantage of celecoxib over diclofenac/ibuprofen was abolished when patients were on concurrent aspirin.

관리 방법

Add a PPI when using celecoxib + aspirin; if the primary goal is GI safety, combining celecoxib with aspirin defeats this purpose.

의학적 면책조항

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.