Afatinib vs Captopril

## Afatinib vs Captopril: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Captopril**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Captopril — 1.9 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Captopril — C9H15NO3S.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Captopril — 217.2850 g/mol.

**Type**: Afatinib — Small molecule; Captopril — Small molecule.