Atezolizumab vs Erlotinib

## Atezolizumab vs Erlotinib: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Erlotinib**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Erlotinib**: Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Erlotinib — 36 hours.

## Chemical Properties

**Molecular Formula**: Atezolizumab — N/A; Erlotinib — C22H23N3O4.

**Molecular Weight**: Atezolizumab — N/A; Erlotinib — 393.4380 g/mol.

**Type**: Atezolizumab — Antibody; Erlotinib — Small molecule.