Cyclosporine vs Methotrexate

## Cyclosporine vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Cyclosporine** and **Methotrexate**.

## Mechanism of Action

**Cyclosporine**: Calcineurin inhibitor suppressing T-cell activation.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Cyclosporine — 6-12 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Cyclosporine — C62H111N11O12; Methotrexate — C20H22N8O5.

**Molecular Weight**: Cyclosporine — 1202.6100 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Cyclosporine — Protein; Methotrexate — Small molecule.