Duloxetine vs Hydrochlorothiazide

## Duloxetine vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Hydrochlorothiazide**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Duloxetine — Small molecule; Hydrochlorothiazide — Small molecule.