Gefitinib vs Tofacitinib

## Gefitinib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Gefitinib** and **Tofacitinib**.

## Mechanism of Action

**Gefitinib**: Selective reversible inhibitor of EGFR tyrosine kinase.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Gefitinib — 48 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Gefitinib — C22H24ClFN4O3; Tofacitinib — C16H20N6O.

**Molecular Weight**: Gefitinib — 446.9000 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Gefitinib — Small molecule; Tofacitinib — Small molecule.