Hydrochlorothiazide vs Losartan

## Hydrochlorothiazide vs Losartan: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Losartan**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Losartan**: Angiotensin II receptor type 1 antagonist.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Losartan — 2 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Losartan — C22H23ClN6O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Losartan — 422.9200 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Losartan — Small molecule.