Lorazepam vs Zolpidem

## Lorazepam vs Zolpidem: Overview

This comparison examines the pharmacological differences between **Lorazepam** and **Zolpidem**.

## Mechanism of Action

**Lorazepam**: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

**Zolpidem**: Selective GABA-A receptor alpha-1 subunit agonist.

## Pharmacokinetics

**Half-life**: Lorazepam — 10-20 hours; Zolpidem — 2.5 hours.

## Chemical Properties

**Molecular Formula**: Lorazepam — C15H10Cl2N2O2; Zolpidem — C19H21N3O.

**Molecular Weight**: Lorazepam — 321.1580 g/mol; Zolpidem — 307.3950 g/mol.

**Type**: Lorazepam — Small molecule; Zolpidem — Small molecule.