Osimertinib vs Selpercatinib

## Osimertinib vs Selpercatinib: Overview

This comparison examines the pharmacological differences between **Osimertinib** and **Selpercatinib**.

## Mechanism of Action

**Osimertinib**: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

## Pharmacokinetics

**Half-life**: Osimertinib — 48 hours; Selpercatinib — N/A.

## Chemical Properties

**Molecular Formula**: Osimertinib — C28H33N7O2; Selpercatinib — N/A.

**Molecular Weight**: Osimertinib — 499.6050 g/mol; Selpercatinib — N/A.

**Type**: Osimertinib — Small molecule; Selpercatinib — Small molecule.