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Acetarsone

CHEMBL1330792 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
275.1 g/mol
LogP
—
Phase
4

Organic arsenicals occupied an early place in antiparasitic chemotherapy, and acetarsone was among them, used against protozoal infections of the intestine and the vagina. The compound disrupts metabolic pathways and structural components essential to the parasite, an action that is not confined to the organism and that reflects the general reactivity of arsenic toward biological thiols. Inherent toxicity of arsenic-containing drugs, together with the arrival of safer and more effective antiparasitic agents, removed it from clinical practice. Its history belongs to the era in which chemotherapy was built on heavy-metal compounds. The molecule is C8H10AsNO5 with a molecular weight near 275.1 g/mol.

An organic arsenic compound that was historically used as an antiparasitic agent to treat intestinal and vaginal infections caused by certain protozoa. Due to the inherent toxicity of arsenic-containing compounds and the availability of safer and more effective antiparasitic medications, it is no longer in clinical use.

Молекулярная масса

275,0900 g/mol

TPSA

107,00 Ų

Терапевтические области

Infectious Disease

Механизм действия

Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)Nc1cc([As](=O)(O)O)ccc1O

                

                

                
                

                    
InChI

                    
InChI=1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H10AsNO5

                    

                    
                    

                        
HBD / HBA

                        
4 / 5

                    

                    
                    

                        
Вращаемые Связи

                        
2

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
An organic arsenic compound that was historically used as an antiparasitic agent to treat intestinal and vaginal infections caused by certain protozoa. Due to the inherent toxicity of arsenic-containing compounds and the availability of safer and more effective antiparasitic medications, it is no longer in clinical use.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acetarsone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1330792.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1985.
                Chemical information database.
            
        
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Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.