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Amitriptyline

CHEMBL629 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
277.4 g/mol
LogP
5.0
Phase
4

A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.

Молекулярная масса

277,4000 g/mol

LogP

5,00

TPSA

3,20 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Pain Management Non-Small Cell Lung Cancer Parkinson's Disease Epilepsy Migraine Schizophrenia Generalized Anxiety Disorder Insomnia Gastroesophageal Reflux Disease Inflammatory Bowel Disease Multiple Sclerosis Stroke Lymphoma Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN(C)CCC=C1c2ccccc2CCc2ccccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H23N

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
Вращаемые Связи

                        
3

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Amitriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL629.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2160.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.