Buclizine
An antihistamine with antiemetic, antivertigo, and mild anxiolytic properties, used to treat motion sickness, vertigo, and nausea. It acts by blocking histamine and muscarinic receptors in the central nervous system. It is also used as an appetite stimulant in some formulations.
Молекулярная масса
433,0000 g/mol
LogP
7,10
TPSA
6,50 Ų
Правило пяти Липинского
Соответствует
Механизм действия
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Структура
Cite this structure
Embed this structure
SMILES
CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1
InChI
InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3
Molecular Formula
C28H33ClN2
HBD / HBA
- / 2
Вращаемые Связи
6
Тяжёлые Атомы
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
An antihistamine with antiemetic, antivertigo, and mild anxiolytic properties, used to treat motion sickness, vertigo, and nausea. It acts by blocking histamine and muscarinic receptors in the central nervous system. It is also used as an appetite stimulant in some formulations.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Buclizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201271. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6729. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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