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Bupropion Hydrochloride

CHEMBL1698 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
276.2 g/mol
LogP
—
Phase
4

The hydrochloride salt form of bupropion, the most widely prescribed formulation used for depression, seasonal affective disorder, and smoking cessation. It is available in immediate-release, sustained-release, and extended-release forms to optimize tolerability. Seizure risk increases at higher doses, requiring caution in at-risk individuals.

Молекулярная масса

276,2000 g/mol

TPSA

29,10 Ų

Терапевтические области

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Epilepsy Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Inflammatory Bowel Disease Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Tuberculosis Heart Failure Cardiovascular Disease Prostate Cancer Colorectal Cancer Leukemia

Механизм действия

Norepinephrine-dopamine reuptake inhibitor (NDRI).

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Norepinephrine-dopamine reuptake inhibitor (NDRI).

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H19Cl2NO

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
The hydrochloride salt form of bupropion, the most widely prescribed formulation used for depression, seasonal affective disorder, and smoking cessation. It is available in immediate-release, sustained-release, and extended-release forms to optimize tolerability. Seizure risk increases at higher doses, requiring caution in at-risk individuals.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Norepinephrine-dopamine reuptake inhibitor (NDRI).

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Bupropion Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1698.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 62884.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.