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Clobazam

CHEMBL70418 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
300.7 g/mol
LogP
2.1
Phase
4

A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.

Молекулярная масса

300,7400 g/mol

LogP

2,10

TPSA

40,60 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Pain Management Asthma Epilepsy Schizophrenia Generalized Anxiety Disorder Insomnia Hypertension Chronic Pain Heart Failure

Механизм действия

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …

2D Структура

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SMILES

                    
CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H13ClN2O2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Вращаемые Связи

                        
1

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Clobazam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL70418.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2789.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.