Deflazacort
A synthetic oxazoline glucocorticoid derived from prednisolone, used as an anti-inflammatory and immunosuppressant and specifically approved for Duchenne muscular dystrophy in the United States. It is considered to have a better safety profile regarding bone loss and weight gain compared to equivalent doses of prednisone.
Молекулярная масса
441,5000 g/mol
LogP
2,00
TPSA
102,00 Ų
Правило пяти Липинского
Соответствует
Терапевтические области
Механизм действия
Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.
2D Структура
Cite this structure
Embed this structure
SMILES
CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C
InChI
InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
Molecular Formula
C25H31NO6
HBD / HBA
1 / 7
Вращаемые Связи
4
Тяжёлые Атомы
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
A synthetic oxazoline glucocorticoid derived from prednisolone, used as an anti-inflammatory and immunosuppressant and specifically approved for Duchenne muscular dystrophy in the United States. It is considered to have a better safety profile regarding bone loss and weight gain compared to equivalent doses of prednisone.
Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.
Yes, Deflazacort is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201891. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 189821. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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